The Red Skelton Show premiered on 30 September 1951. It was one of the first variety shows to make the successful transition from radio to television and one of the longest running variety series. For two seasons Red continued his radio show while also doing his TV show.

The series originally aired in a half-hour show on NBC. After two seasons he switched to CBS, and The Red Skelton Show became a Tuesday night viewing routine for most American families from 1954 to 1970.

The format of the series was similar to Skelton's radio program. Each show began with Skelton performing a monologue based on topical material, followed by a musical interlude. He would then perform in a series of blackout sketches featuring one or more of his characters.

The sketches were a mixture of new material and old routines (including his popular "Guzzler's Gin") perfected over the years in vaudeville and in nightclubs. At the end of the program, Skelton would become serious and express his gratitude to his audience for their love and laughter. His signature closing line became "Good night and may God bless."

The Red Skelton Show, unlike other variety series, did not solely rely on guest stars every week. Skelton had a strong group of support players, most of whom had worked with him on his radio program. They included Benny Rubin, Hans Conried, Mel Blanc, and Verna Felton.

Most of Skelton's characters were first developed for radio and worked equally well on television. Among the best known were Junior the Mean Widdle Kid (who was famous for his expression, "I Dood It"), country boy Clem Kadiddlehopper, Sheriff Deadeye, boxer Cauliflower McPugg, drunkard Willy Lump-Lump, and con man San Fernando Red. Skelton had a reputation for his extensive use of "headware." Each character had his own specific hat, which Skelton used as a means to find the center of each personality.

The only television addition to his repertoire of characters was Freddie the Freeloader, who became one of his most beloved characters.

Skelton's forte was his use of slapstick. He seemed oblivious to physical punishment and often ended his vaudeville act by falling off the stage into the orchestra pit. One of his most popular pieces was created for his premiere show. At the end of his monologue, while Skelton was taking a bow, two hands reached out from under the curtain, grabbed him by the ankles, and swept him off the stage.

Many stars got their start on The Red Skelton Show. Johnny Carson, one of Skelton's writers, was called upon to fill in for the star when, in 1954, Skelton injured himself during a rehearsal. The Rolling Stones made one of their earliest American appearances on the show in 1964, and The Jackson Five, with Michael Jackson also made an appearance.

Although the series remained among the top 20 rated shows, CBS canceled it in 1970, citing high production costs. But it was also the case that Skelton's main audience was very young viewers and speculation suggested that the network wanted to increase its audience share of young adults. The next season, Skelton returned to NBC in a half-hour format on Monday night, but the new show lasted only one season.

During the run of his variety series, Skelton was also able to demonstrate his dramatic abilities. He played the punch-drunk fighter, Buddy McCoy, in Playhouse 90's The Big Slide (CBS, 1956) for which he was nominated for an Emmy award as Best Actor.  Susan Gibberman from Museum of Broadcast Communications.